"Isolation in creative work is an onerous thing. Better to have negative criticism than nothing at all."

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The hallucinogens produce visionary states, sort of, but morphine and its derivatives decrease awareness of inner processes, thoughts and feelings. They are pain killers; pure and simple. They are absolutely contraindicated for creative work, and I include in the lot alcohol, morphine, barbiturates, tranquilizers the whole spectrum of sedative drugs.

— William S. Burroughs