"In any fairly large and talkative community such as a university there is always the danger that those who think alike should gravitate together where they will henceforth encounter opposition only in the emasculated form of rumour that the outsiders say thus and thus. The absent are easily refuted, complacent dogmatism thrives, and differences of opinion are embittered by the group hostility. Each group hears not the best, but the worst, that the other group can say."

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The statistical method is required in the interpretation of figures which are at the mercy of numerous influences, and its object is to determine whether individual influences can be isolated and their effects measured. The essence of the method lies in the determination that we are really comparing like with like, and that we have not overlooked a relevant factor which is present in Group A and absent from Group B. The variability of human beings in their illnesses and in their reactions to them is a fundamental reason for the planned clinical trial and not against it.

— Austin Bradford Hill