"You think maybe if you just work harder and faster, you can hold off the chaos, but then one day you’re changing a patio light bulb with a five-year life span and you realize how you’ll only be changing this light maybe ten more times before you’ll be dead."

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[Locating, from scratch, the gene related to a disease is like] trying to find a burned-out light bulb in a house located somewhere between the East and West coasts without knowing the state, much less the town or street the house is on.

— Francis Collins