"Despite their differences, pride, shame, and guilt all activate similar neural circuits, including the dorsomedial prefrontal cortex, amygdala, insula, and the nucleus accumbens. Interestingly, pride is the most powerful of these emotions at triggering activity in these regions - except in the nucleus accumbens, where guilt and shame win out. This explains why it can be so appealing to heap guilt and shame on ourselves - they're activating the brain's reward center."

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Difficulties with material things often come to remind us that our concentration should be on spiritual things instead of material things. Sometimes difficulties of the body come to show that the body is just a transient garment, and that the reality is the indestructible essence which activates the body. But when we can say, 'Thank God for problems which are sent for our spiritual growth.' They are no longer problems. They then become opportunities.

— Peace Pilgrim