"It is emphatically the case that life could not arise spontaneously in a primeval soup of any kind.... Furthermore, no geological evidence indicates an organic soup ever existed on this planet. We may therefore with fairness call this scenario the myth of the pre-biotic soup."

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Neo-Darwinian language and conceptual structure itself ensures scientific failure: Major questions posed by zoologists cannot be answered from inside the neo-Darwinian straitjacket. Such questions include, for example, 'How do new structures arise in evolution?' 'Why, given so much environmental change, is stasis so prevalent in evolution as seen in the fossil record?' 'How did one group of organisms or set of macromolecules evolve from another?' The importance of these questions is not at issue; it is just that neo-Darwinians, restricted by their resuppositions, cannot answer them.

— Lynn Margulis