"I am certainly not regenerating French art, but am struggling hard to accomplish something on an unlucky piece of paper which has done me no harm at all, and on which, believe me, I am doing nothing that is good... I hope things will improve eventually; as it is, I am pretty wretched."

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Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired. Evolution has produced chemical compounds exquisitely organized to accomplish the most complicated and delicate of tasks. Many organic chemists viewing crystal structures of enzyme systems or nucleic acids and knowing the marvels of specificity of the immune systems must dream of designing and synthesizing simpler organic compounds that imitate working features of these naturally occurring compounds.

— Donald Cram