"Whether or not science can be applied to that mental construct [i.e. the designed entity] is a matter of availability. If there is body of scientific knowledge that can be applied, then it would be foolish not to exploit it. However, if there is none, it does not mean that the thing cannot be designed, made, and used safely."

Next Quote

I've gone to big stadium rock concerts at some artist's invitation, and there's this invariable, fascinating and rather sad situation of concentric circles of availability. There are Green Rooms within Green Rooms literally within Green Rooms. There are seven or eight degrees of exclusivity, and within each circle of exclusivity, everyone is so happy to be there, and they don't know that the next level exists.

— William Gibson