"We need to move beyond asking what drug will treat the symptoms, and instead ask what mechanism creates altered neurochemical or neurobiological function or systemic physiological change."

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You may wonder, 'How can I leave it all behind if I am just coming back to it? How can I make a new beginning if I simply return to the old? The answer lies in the return. You will not come back to the 'same old thing. What you return to has changed because you have changed. Your perceptions will be altered. You will not incorporate into the same body, status, or world you left behind. The river has been flowing while you were gone. Now it does not look like the same river.

— Stephen Foster