"How do blind people know when they're done wiping their ass?"

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Let's take something like antidepressant medications. There's decent science saying it has an effect, but it's shockingly small after you control for penetration of the blind, people knowing that they're getting the active pills versus sugar pills, if you use an active control. It's probably only a few points. But it's a multi, multibillion-dollar industry. And by the way, has huge side effects. 40 percent of the people taking them have significant sexual side effects. And that's just one. A single antidepressant medication can be worth a billion dollars to a company.

— Steven C. Hayes