"I wanted to explore cancer not just biologically, but metaphorically. The idea that tuberculosis in the 19th century possessed the same kind of frightening and decaying quality was very interesting to me, and it seemed that one could explore the idea that every age defined its own illness."

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One of the central developments of 19th century mathematics involved a dramatic increase in the standards of mathematical rigor. This was for a variety of reasons, but the short version is that there was a need to be stricter about the standards of proof, because certain familiar modes of reasoning had started to lead people astray, or at least threatened to do so.

— Richard F. Heck