"Any one who has studied the history of science knows that almost every great step therein has been made by the "anticipation of Nature," that is, by the invention of hypotheses, which, though verifiable, often had very little foundation to start with; and, not unfrequently, in spite of a long career of usefulness, turned out to be wholly erroneous in the long run."

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Science is not a system of certain, or -established, statements; nor is it a system which steadily advances towards a state of finality... And our guesses are guided by the unscientific, the metaphysical (though biologically explicable) faith in laws, in regularities which we can uncover-discover. Like Bacon, we might describe our own contemporary science-'the method of reasoning which men now ordinarily apply to nature'-as consisting of 'anticipations, rash and premature' and as 'prejudices'.

— Karl Popper