"The great and invigorating influences in American life have been the unorthodox: the people who challenge an existing institution or way of life, or say and do things that make people think."

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One of the manifestations of depression for me is that I lose my will. And I thereby lose my ability to focus. I don't think I'll ever have the day-to-day consistency in my performance that something like This American Life has. If I'm not depressed and I'm on and I can focus and I can think through something hard and without interruption and without existential emptiness that comes from depression, that gives me - not mania. But I exalt. I exalt in not being depressed.

— Rachel Maddow