"Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures]."

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My own take on the word "transgender" is that it's an umbrella term for anyone who breaks any rules, laws, guidelines or protocol of gender. So, to really be an ally, it's important that you recognize and embrace your own transgender nature. Really, I haven't met a single person who doesn't break some rule of gender. In other words, we will assimilate you. Resistance is futile.

— Kate Bornstein