"I think the difference is that Angelina didn't need any CGI enhancement and I did! You can't really think about some things too much, you just get on with it and do it. It's about the way you move and the way you sound."

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CGI means, just to be clear, creating any type of image with a computer. Basically, starting off with nothing, or with images and manipulating them. The way we did it, everything was actual photographed images. A lot of that stuff was shot through a microscope of chemical reactions, yeast growing, lots of weird things, by Peter Parks. We put it into a computer and collaged it, manipulated it. Meaning we digitally shaped it to fit with other images. But there was no computer-generated imagery at all.

— Darren Aronofsky